hypertension, type 2 diabetes mellitus, blood pressure, endothelial function, elderly patients, fixed combination, ramipril, hydrochlorothiazide


Arterial hypertension and diabetes mellitus are comorbid diseases, they are interconnected not only by common pathophysiological mechanisms of development, but also by similar cardiovascular complications. This relationship is due to the activation of the renin-angiotensin-aldosterone system, which underlies the remodeling of the cardiovascular system and the development of complications. According to current clinical guidelines, ACE inhibitors are the drugs of choice for the treatment of hypertension in combination with diabetes mellitus. The use of ACE inhibitors in patients with hypertension and diabetes is accompanied by a decrease in the relative risk of cardiovascular outcomes and mortality. This article presents the results of a clinical study of the combined drug Co-ramaz (ramipril and hydrochlorothiazide) in elderly patients with arterial hypertension and diabetes mellitus.



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