ischemic heart disease, chronic coronary syndromes, antiarrhythmic, antianginal and anti-ischemic effect


The article presents data on the effectiveness the drug fructose-1,6-diphosphate in patients with chronic forms of coronary heart disease. Drugs of this class provide reduction of oxygen demand of ischemic myocardium by optimizing energy exchange at a certain residual level of blood supply (including in the peri-infarction zone) by reducing fatty acid oxidation in mitochondria and stimulating glycolysis, requiring 13% fewer oxygen molecules. This preserves myocardial viability in the ischaemic zone. The results of the study showed that the inclusion of the drug fructose-1,6-diphosphate in the complex therapy of coronary heart disease makes it possible to accelerate the dynamics of ECG, has anti-inflammatory, antiarrhythmic, antianginal and anti-ischemic effect, thereby improving the quality of life of patients with chronic forms of coronary heart disease.



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