ulcerative colitis, inflammatory bowel disease, extraintestinal manifestations, liver


Inflammatory bowel disease, which includes ulcerative colitis, remains one of the serious problems of the modern clinic of internal diseases. Inflammatory bowel disease is a systemic disease with an extremely diverse clinical picture of intestinal damage and a wide range of possible extraintestinal manifestations, which makes initial diagnosis extremely difficult. Often, intestinal symptoms of the disease may be absent or subclinical. This paper presents an overview of studies on extraintestinal complications. Extraintestinal lesions that occur in inflammatory bowel disease are very diverse. It is very important to remember that often extraintestinal lesions manifest earlier than intestinal symptoms. The correct interpretation of extraintestinal symptoms contributes to the diagnosis and the appointment of timely adequate therapy.



Adler, G. Crohn's disease and ulcerative colitis / G. Adler; per. with him. A.A. Sheptulina.—M.: GEOTAR-MED, 2001.—500 p.

Belousova, E.A. Ulcerative colitis and Crohn's disease / E.A. Belousova.—M.: Triada, 2002.—130 p.

Grigoriev, P.Ya. Reference guide to gastroenterology / P.Ya.Grigoriev, E.P.Yakovenko.—M.: Med. news agency, 1997.—480 p.

Grigorieva, G.A. Nonspecific ulcerative colitis and Crohn's disease: diagnosis and treatment of complicated forms / G.A. Grigorieva, N.Yu. Meshalkina, I.B. Repina // Clinical perspectives of gastroenterology, hepatology.—2002.—No. 5.—P.34— 39. 5. Inflammatory Bowel Disease: From Bench to Bedside / ed. by S.R.Targan, F.Shanahan, L.C.Karp.—2nd ed.—Kluwer.Academic Publishers, 2003.—904 p.

Sekacheva M.I. Modern aspects of the treatment of nonspecific ulcerative colitis; results of evidence-based medicine // Consilium medicum. - 2003. - No. 3. - P. 18–22

Brief guide to gastroenterology / ed. V.T. Ivashkina, F.I. Komarova, S.I. Rapoport. - M .: OOO Publishing House. house "M-Vesti", 2001. - 458 p.

Stack W.A., Long R.G., Hawkwy C.J. Short-and long-term outcome of patients treated with cyclosporine for severe acute ulcerative colitis. Aliment Pharmacologic There 1998; 12:973-8.

Shaposhnikov V.I. To the question of the pathogenesis of nonspecific ulcerative colitis // Successes of modern natural science. - 2013. - No. 7. - P. 27-29;

Kushnir I.E. Extraintestinal manifestations of chronic inflammatory bowel disease. Gastroenterology. Hepatology. Coloproctology, No. 7.

Dorofeev A.E., Dorofeeva A.A. Liver damage in patients with nonspecific ulcerative colitis. Gastroenterology, Volume 51, No. 2, 2017.

Dorofeev A.E., editor. Diagnosis and treatment of diseases of the gastrointestinal tract. Donetsk: Nord-Press; 2009. 366 p.

Geboes K, Riddell R, Ost A, Jensfelt B, Persson T, Lofberg R. A reproducible grading scale for histological assessment of inflammation in ulcerative colitis. gut. 2000 Sep;47[3]:404-9. doi: 10.1136/gut.47.3.404.

Kostyukevich S.V., Anichkov N.M., Ivanova B.F., Oreshko L.S., Kudryashova G.P., Medvedeva O.A., Smirnova O.A. Endocrine cells of the rectal epithelium in a healthy state, with ulcerative colitis and irritable bowel syndrome in the treatment of prednisolone and salofalk and in the absence of treatment. Archive of pathology. 2004;4:23-27.

Linevskiy Yu.V., Linevskaya K.Yu., Voronin K.A. Crohn's disease: practical aspects of the problem. News of medicine and pharmacy. 2009;304:43-50.

Vorobyov G.I., Khalif I.L., Malakhova N.S., Kapuller L.L., Veselov V.V., Mikhailova T.L. Endoscopic and morphological features of the colon mucosa in patients with distal ulcerative colitis.

Russian journal of gastroenterology, hepatology, coloproctology. 2006;16[1]:80-86.